Mary Jane Watson is Peter Parker's childhood female best friend. She has a heavy interest in journalism that may get her working for J. Jonah Jameson. One things for sure is that she always has Peter's back. In Season 4, she bonded with the Carnage symbiote and became the Carnage Queen, and later became Spider-Woman.
Mary Jane has been dear friends with Peter since they were kids and attempted to get serious when they turned 12. It proved to be too much for them and they became great friends.
After the battle with Trapster, Mary Jane reviewed a report by John Jameson, anxious to get her big break as a journalist. She told this to Peter, who isn't a fan of the idea. She would later be present when The Frightful Four (sans Trapster) attacked their school, when Harry took a blow for her.[1] She later informed Peter she wished to interview Spider-Man and Peter considered giving her an exclusive but feels she will determine already if it is him.
Further on, she befriended Nova, Spider-man's superhero ally much to Peter chargrin. She called Peter (as Spider-Man) when he was battling Doombots, along with his other teammates. She called Peter again after the crisis was averted, demanded to give Nova his homework. Peter, tired after his battle, caved in and gave the phone to Nova.